脑科学研究团队返回

沈沁
清华大学医学院 副教授
办公室: D106,医学科学楼
办公电话: +86 10 6279 8087
电子邮件: shenqin@tsinghua.edu.cn
[研究兴趣]

​1. 调节神经干细胞的自我更新和命运选择的分子机制
2. 神经干细胞和微环境之间的相互作用,这是干细胞治疗的关键
3. 干细胞在神经系统疾病中的所起的作用
4. 使用人类ES和iPS-起源的神经干细胞模拟大脑发育型功能障碍

[简历] 2010-现在  副教授,清华大学医学院基础医学系
2007-2010  助理教授,纽约神经干细胞研究所,美国
2006-2010  助理教授,Albany Medical Center, Center for Neuropharmacology and Neuroscience, 纽约州,美国
2001-2006  博士后, Albany Medical College, Center for Neuropharmacology and Neuroscience
1996-2001  博士, Albany Medical College, Center for Neuropharmacology and Neuroscience
1991-1996  研究和教学助理, 神经生物学系,State Key Laboratory of Medical Neurobiology, 上海医科大学(现复旦大学医学院)
1986-1991  学士学位,药理学,上海医科大学药学院
[部分发表]

1. Kokovay E, Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q*, Temple S*.(2012)VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression.Cell Stem Cell. 11(2):220-30. *co-corresponding authors
2. Chuang, S.M., Wang, Y., Wang, Q., Liu, K.M., Shen Q*.(2011) Ebf2 Marks Early Cortical Neurogenesis and Regulates the Generation of Cajal-Retzius Neurons in the Developing Cerebral Cortex. Dev Neurosci. 33(6):479-93. *corresponding author
3. Erzsebet, K., Goderie, S., Wang, Y., Lin, G., Roysam, B., Shen, Q., Temple, S. (2010) Adult SVZ lineage cells home to and leave the niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell 7(2):163-173
4. Shen, Q.* and Temple, S. (2009) Fine control: microRNA regulates adult neurogenesis. Nature Neurosci.12 (4): 369-370
5. Kokovay, E., Shen, Q., Temple, S. (2008) The incredible elastic brain: how neural stem cells expand our minds. Neuron 60(3):420-9.
6. Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.M., Goderie, S.K., Roysam, B., Temple, S. (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3(3):289-300.
7. Shen, Q.*, Wang, Y., Dimos, J.T., Fasano, C.A., Phoenix, T.N., Lemischka, I.R., Ivanova, N.B., Stifani, S., Morrisey, E.E., Temple, S. (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nature Neurosci. 9(6):743-51
8. Shen, Q., Goderie, S., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., Temple, S. (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340
9. Li, H.S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., Jan, Y.N. (2003) Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40(6):1105-18.
10. Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002) Asymmetric m-Numb distribution is critical for asymmetric cell division of mouse cerebral cortical progenitor cells. Development 129:4843-4853.
11. Qian, X., Shen, Q.,Goderie, S., He, W., Capela, A.M., and Temple, S. (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical cells. Neuron 28:69-80. co-first author
12. Qian, X., Goderie, S., Shen, Q., Stern, J. H. and Temple, S. (1998)Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells. Development 125:3143-3152


全部发表情点击此处:
http://www.ncbi.nlm.nih.gov/sites/myncbi/collections/public/1DOLC8cSR--rigvXLHK3wFQQs/?sort=date&direction=descending