脑科学研究团队返回

鲁白
清华医学院教授、常务副院长
办公室地址:医学科学楼 A311
办公电话:86-10-6278 5101
电子邮件:bai.lu@biomed.tsinghua.edu.cn
博客: http://blog.sciencenet.cn/u/lubai
[研究兴趣] 神经科学,转化医学,药物研发
[我和科学] 科学对我来说不仅仅是一种职业,而是一种生活方式 – 帮助解决社会问题并满足我对于科学的好奇心。在我的实验室里,学生将学习如何辩证地思考,如何创造性地解决问题。
[简历] 2013 – 现在 清华大学医学院教授、常务副院长
2009-2013 葛兰素史克公司中国研发中心生物技术副总裁
2008-2013 清华大学医学院客座教授
2004-2009 美国国立卫生研究院,NIMH, GCAP项目(Program in Gene, Cognition and Psychosis),分子神经生物学副主任
2002-2009 美国国立卫生研究院,NICHD,神经发育和可塑性研究部门负责人
1996-2002 美国国立卫生研究院,NICHD,突触发育和可塑性研究组负责人
1993-1995 助理教授,Roche分子生物研究所,美国新泽西州
1990-1993 洛克菲勒大学Paul Greengar实验室和哥伦比亚大学Mu-ming Poo实验室 博士后
1990 美国康奈尔大学医学院博士(导师: Ira B. Black)
1982 华东师范大学,生物学学士
[部分发表]

1.K. Sakata, K. Martinowich(co-first author), N. H. Woo, R. Schlosser, L. Shen, B. Lu (2013) Activity-dependentBDNF transcription regulates hippocampal late-phase LTP and behavioral perseverance. Proc. Natl. Acad. Sci. USA.  110(37):15103-8.

2.H. –S. Je, F. Yang, Y. Ji, G. Nagappan, B. Hempstead, and B. Lu (2012).Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.Proc. Natl. Acad. Sci. USA.109, 15924-15929.

3.J. Y. Kim, C. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. S. Clair, K. Christian, J. H. Callicott, D. R. Weinberger, H. Song and G. -l. Ming (2012) Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia. Cell. 5, 1051-1064.

4.K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. Hökfelt, A. Fisahn, B. Xu, and B. Lu (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206.

5.Y. Jiao, Z. Zhang, C. Zhang, X. Wang,  K. Sakata, B. Lu, (co-corresponding author), and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136.

6.Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309.

7.B. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204.

8.T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche (co-corresponding author), and B. Lu (2009) Dysbindinregulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400.

9.Y. Ji, F. Yang, F. Papaleo (co-first author), H. Wang, W. Gao, D. R. Weinberger, and B. Lu (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98.

10.S. J, Huffaker, J. Chen, K. Nicodemus, F Sambataro, F. Yang, V. Mattay, B. Lipska, T. M. Hyde, J. Song, D. Rujescu, I. Giegling, K. Mayilyan, M. J. Proust, A. Soghoyan, G. Caforio, J. H. Callicott, A. Bertolino, A. Meyer-Lindenberg, J. Chang, Y. Ji, M. Egan, T. Goldberg, K. E. Kleinman, B. Lu, D. R. Weinberger (2009) A novel, primate-specific brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Medicine 5, 509-518. Commented in the same issue by Horvath and Mirnics, 488-590.

11.K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947.

12.G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272. Highlights by Katherine Whalley, Nature Rev. Neuroscie. 10, 168-169.  Commented in Alzheimer Research Forum by Lucia Tapia-Arancibia as well as Margaret Fahnestock.

13.J. J. An, K. Gharami, G. –Y. Liao, N. H. Woo, A. G. Lau, F. Vanevski, E. R. Torre, K. R. Jones, Y. Feng, B. Lu, B. Xu (2008) Distinct role of long 3’UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 134, 175-187.

14.X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu(co-corresponding author), and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158.

15.N. H. Woo, H.K. Teng, C. –J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077.Highlights by Morgan Sheng, Nature.442, 4.

16.Y. Ji, P. T. Pang, L. Feng, and B. Lu (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172. Feature article in AfCS Nature the signaling gateway, Feb, 2005, commented by MyrtoRaftopoulous.

17.P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491. Highlights by Rachel Jones, Nature Rev. Neuroscie.5, 898.Commented in Sci STKE, 255 tw378.Worldwide news coverage.

18.M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, A. Bertolino, E. Zaistev, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger (2003)The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell112, 257-269. With Preview by John Garbriele and Alison Preston, Cell 112, 144-145; News article by Jean Marx, Science, 299, 639-640. and Highlights by Magdalena Skipper, Nature Rev. Genetics. 4, 163.Worldwide news coverage.

19.C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu (2001) Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release. Neuron  32, 99-112.

20.F. Yang, L. Feng, Z. Fang, S. W. Johnson, J. Du, L. Shen, C. -P. Wu, and B. Lu (2001) GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons.  Nature Neurosci. 4, 1071-1078.

21.F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong, and B. Lu (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation.  Nature Neurosci.  4, 19-28. With News and Views comments by David Kaplan and Ellis Copper, 4, 5-7.

22.A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus.  Nature  381, 706-709.              

23.P. Olafsson, T. Wang, and B. Lu (1995)  Molecular cloning and functional characterization of Xenopus Ca2+- binding protein frequenin.  Proc. Natl. Acad. Sci. USA   92, 8001-8005.

24.T. Wang, Z. Xie, and B. Lu (1995) Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses.  Nature  374, 262-266.         Y.g-aminobutyratergic synaptic transmission in cortical neurons.    91, 12341-12345.  

25.B. Lu, W. -m. Fu, P. Greengard and M. -m. Poo (1993) Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction.  Nature  363, 76-79.

26.J. Alder, .B. Lu, F. Valtorta, P. Greengard and M. -m. Poo (1992) Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: Requirement for synaptophysin. Science257, 657-661.B. Lu, P. Greengard and M. -m. Poo (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron  8, 521-529.              

27.B. Lu, M. Yokoyama, C. F. Dreyfus and I. B. Black (1991) Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 88, 6289-6292.