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                         鲁白         
        
            
研究员,清华-IDG/麦戈文脑科学研究院
教授,清华药学院
            
办公室地址:医学科学楼 A311
办公电话:86-10-6278 5101
电子邮件:bai.lu@biomed.tsinghua.edu.cn
博客: http://blog.sciencenet.cn/u/lubai
                     
        
                        [研究兴趣]                          神经科学,转化医学,药物研发         
        
                            [我和科学]                              科学对我来说不仅仅是一种职业,而是一种生活方式 – 帮助解决社会问题并满足我对于科学的好奇心。在我的实验室里,学生将学习如何辩证地思考,如何创造性地解决问题。         
        
                            [简历]                             
2016-至今    清华-IDG/麦戈文脑科学研究院研究员
2016-至今    清华大学药学院教授
2013-2016    清华大学医学院教授
2009-2013    葛兰素史克公司中国研发中心生物技术副总裁
2008-2013    清华大学医学院客座教授
2004-2009   美国国立卫生研究院,NIMH, GCAP项目(Program in Gene, Cognition and Psychosis),分子神经生物学副主任
2002-2009   美国国立卫生研究院,NICHD,神经发育和可塑性研究部门负责人
1996-2002   美国国立卫生研究院,NICHD,突触发育和可塑性研究组负责人
1993-1995   助理教授,Roche分子生物研究所,美国新泽西州
1990-1993   洛克菲勒大学Paul Greengar实验室和哥伦比亚大学Mu-ming Poo实验室 博士后
1990          美国康奈尔大学医学院博士(导师: Ira B. Black)
1982          华东师范大学,生物学学士         
        
                                         [部分发表]                             

W. Guo, G. Nagappan and B. Lu*. (2018) Differential effects of transient and sustained activation of BDNF-TrkB signaling. Developmental Neurobiology. DOI 10.1002/dneu.22592.

K. Pang, H. You, Y. Chen, P. Chu, M. Hu5, J. -Y Shen, W. Guo, C. Xie, Bai Lu* (2017) MagR alone is insufficient to confer cellular calcium responses to magnetic stimulation. Frontiers Neural Circuits. 11:11.doi: 10.3389/fncir.2017.00011.

J. Guo, Y. Ji, Y. Ding, W. Jiang, Y. Sun, B. Lu*, G. Nagappan (2016) BDNF-pro peptide regulates dendritic spines via caspase-3. Cell Death & Differentiation. 7(6):e2264. doi: 10.1038/cddis.2016.166.

P. T. Pang, G. Nagappan, W. Guo, and B. Lu*(2016) Extracellular and intracellular cleavages of proBDNF required at two distinct stages of late phase LTP (L-LTP). Science of Learning. Published online 5,2016. doi:10.1038/npjscilearn.2016.3

W. Guo, Y. Ji, S. Wang, Y. Sun, B. Lu* (2014) Neuronal activity alters BDNF- TrkB signaling kinetics and downstream functions. J. Cell Sci. 127, 2249-2260.

B. Lu* and G. Nagappan (2014) BDNF and synaptic plasticity. Handbook of Experimental Pharmacology. Springer-Verlag. Berlin. 233-250.

B. Lu*, P. J Nathan, Olivier Blin, G. Nagappan (2013) Synaptic function as a preclinical and experimental medicine readout for disease-modifying therapy in Alzheimer’s Disease. Drug Discovery Today: Therapeutic Strategies. 10, e99-104.

B. Lu*, G. Nagappan, X. Guan, P. J. Nathan and P. Wren (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature Review Neuroscience. 14(6):401-16.

K. Sakata, K. Martinowich(co-first author), N. H. Woo, R. Schlosser, L. Shen, B. Lu*

(2013) Activity-dependentBDNF transcription regulates hippocampal late-phase LTP and behavioral perseverance. Proc. Natl. Acad. Sci. USA.  110(37):15103-8.

H. –S. Je, F. Yang, Y. Ji, G. Nagappan, B. Hempstead, and B. Lu* (2012).Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.Proc. Natl. Acad. Sci. USA.109, 15924-15929.

K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. Hökfelt, A. Fisahn, B. Xu, and B. Lu* (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206.

Y. Jiao, Z. Zhang, C. Zhang, X. Wang,  K. Sakata, B. Lu*, and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136.

Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu* (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309.

B. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu* (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204.

T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche, and B. Lu* (2009) Dysbindinregulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400.

Y. Ji, F. Yang, F. Papaleo, H. Wang, W. Gao, D. R. Weinberger, and B. Lu* (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98.

K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu* (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947.

G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu* (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272.

X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu*, and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158.

N. H. Woo, H.K. Teng, C.J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu* (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077.

Y. Ji, P. T. Pang, L. Feng, and B. Lu* (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172.

P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu* (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491.

M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, A. Bertolino, E. Zaistev, B. Gold, D. Goldman, M. Dean, B. Lu*,and D. R. Weinberger (2003)The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell112, 257-269.

C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu* (2001) Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release. Neuron  32, 99-112.

F. Yang, L. Feng, Z. Fang, S. W. Johnson, J. Du, L. Shen, C. -P. Wu, and B. Lu* (2001) GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons.  Nature Neurosci. 4, 1071-1078.

F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong, and B. Lu* (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation.  Nature Neurosci.  4, 19-28.

A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu* (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus.  Nature  381, 706-709.              

P. Olafsson, T. Wang, and B. Lu* (1995)  Molecular cloning and functional characterization of Xenopus Ca2+- binding protein frequenin.  Proc. Natl. Acad. Sci. USA   92, 8001-8005.

T. Wang, Z. Xie, and B. Lu* (1995) Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses.  Nature  374, 262-266.        

B. Lu*, W. -m. Fu, P. Greengard and M. -m. Poo (1993) Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction.  Nature  363, 76-79.

B. Lu*, P. Greengard and M. -m. Poo (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron  8, 521-529.              

B. Lu*, M. Yokoyama, C. F. Dreyfus and I. B. Black (1991) Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 88, 6289-6292.          

                     
                 
        
    
    
        
            
                    
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