Hong, Bo

PI, IDG/McGovern Institute, Tsinghua University
PI, School of Medicine, Tsinghua University
Office Phone: +86-10-62795985
Fax: +86-10-62792416
Email: hongbo@tsinghua.edu.cn

[Research Focus]

1. Speech network analysis of human brain
2. Complex sound processing in rat midbrain
3. Brain computer interfaces

We may take it for granted of our ability of speaking and listening in daily communication. Surprisingly, we know very little about the brain mechanism of this magic cycle of speech production and perception. Millions of people are suffering from hearing and communication disorder, hoping for innovative treatment and rehabilitation. In my lab, we are searching for the neural code of sound and speech representation in the brain. We look at very precise firing of single neurons in the rat brain, to identify neural circuits accounting for the processing of complex sounds. Meanwhile, collaborating with neurosurgeons, the speech-processing network of human brain is investigated by checking the population activity from the surface of patients’ brain. Putting these puzzle pieces together, a picture of speaking and listening brain is emerging from the massive neural data. Besides helping patients, the neural circuits and codes that we are finding will surely be a crucial hint of developing a smarter speech recognition system, like Siri on your cell phone.

[Education & Experience]

2013-Presnet   PI, IDG/McGovern Institute, Tsinghua University
2005-Present   PI, Dept. of Biomedical Engineering, School of Medicine, Tsinghua University
2004-2005       Visiting Faculty, Dept. of Biomedical Engineering, School of Medicine, Johns Hopkins University
2001-2005       Assistant Professor, Dept. of Biomedical Engineering, School of Medicine, Tsinghua University
1996-2001       Ph.D. Biomedical Engineering, Tsinghua University
1999-2000       Research Assistant, Dept. of Psychology, Chinese University of Hong Kong
1991-1996       B.S. Biomedical Engineering, Tsinghua University

[Selected Publications]

  • ZhangY, ZhouW, Wang S, Zhou Q, Wang H, Zhang B, Huang J, Hong Bo*,Wang X*. The Roles of Subdivisions of Human Insula in Emotion Perception and Auditory Processing. Cerebral Cortex, 2018:1~12.
  • Si X, Zhou W, Hong B*. Cooperative cortical network for categorical processing of Chinese lexical tone. PNAS. 2017, 114(46):12303~12308.
  • Fox MD,Qian T,Madsen JR,Wang D,Li M,Ge M,Zuo HC,Groppe DM,Mehta AD,Hong B*,Liu H*. Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. NeuroImage.  2016.1.1, 124:714~723.
  • Wang D, Buckner RL, Fox MD, Holt DJ, Holmes AJ, Stoecklein S, Langs G, Pan R, Qian T, Li K, Baker JT, Stufflebeam SM, Wang K, Wang X, Hong B*, Liu H. Parcellating cortical functional networks in individuals. Nat Neurosci. 2015,18(12):1853-60.
  • Shen L,Zhao L,Hong B*. Frequency-specific adaptation and its underlying circuit model in the auditory midbrain. Frontiers in Neural Circuits. 9:55, eCollection 2015.
  • Zhang D,Song H,Xu R,Zhou W,Ling Z*,Hong B*. Toward a minimally invasive brain-computer interface using a single subdural channel: A visual speller study,NeuroImage. 2013,71:30~41.  
  • Qian T,Zhou W,Ling Z,Gao S,Liu H,Hong B*. Fast presurgical functional mapping using task-related intracranial high gamma activity Laboratory investigation. Journal of Neurosurgery. 2013,119(1):26~36.
  • Xu H,Zhang D,Ouyang M,Hong B*. Employing an active mental task to enhance the performance of auditory attention-based brain–computer interfaces. Clinical Neurophysiology. 2013,124(1):83~90.
  • Zhang D, Song H, Xu H, Gao S, Hong B*. An online N200 speller: integrating the spatial profile for the detection of the non-control state. Journal of Neural Engineering, 9(2): 026016, 2012.
  • Zhao L, Liu Y, Shen L, Feng L, Hong B*. Stimulus-specific adaptation and its dynamics in the inferior colliculus of rat. Neuroscience. 181:163-174, 2011.
  • Guo J, Gao S, Hong B*. An auditory brain computer interface using active mental response. IEEE Trans. Neural Systems and Rehabilitation Engineering,18(3):230-5, 2010.
  • Liu T, Goldberg L, Gao S, Hong B*. An online brain-computer interface using non-flashing visual evoked potentials. Journal of Neural Engineering, 7(3):036003. 2010.