Lu, Bai

PI, IDG/McGovern Institute, Tsinghua University
Professor, School of Phamaceutical Sciences, Tsinghua University
Office: Medical Sciences Building A311
Office Phone: 86-10-6278 5101

[Research Focus]

Neuroscience, translational research, drug discovery.
Science to me is not just a profession, but a way of life – to help addressing societal needs, and to satisfy my intellectual curiosity. Students in my lab will learn how to think critically, and how to solve problems creatively.

[Education & Experience]

2016-Present    PI, DG/McGovern Institute, Tsinghua University
2016-Present    Professor, School of Phamaceutical Sciences, Tsinghua University
2013-2016        Professor, School of Medicine, Tsinghua Univ., Beijing, China
2009-2013        Vice President, Biology, GlaxoSmithKline, R&D China, Shanghai, China
2008-2013        Adjunct Professor, School of Medicine, Tsnghua Univ., Beijing, China.
2004-2009        Associate Director of Molecular Neurobiology, Program in Gene, Cognition and Psychosis (GCAP), NIMH, NIH, Bethesda, M. D.
2002-2009        Chief, Section on Neural Development and Plasticity, NICHD, NIH, Bethesda, M. D.
1996-2002        Chief, Unit on Synapse Development and Plasticity, NICHD, NIH, Bethesda, M. D.
1993-1995        Assistant Prof., Roche Institute of Molecular Biology, Nutley, N. J.
1990-1993        Postdoctoral Fellow, with Paul Greengard, Rockefeller Univ. and Mu-ming Poo, Columbia Univ., New York, N. Y.
1990                 Ph.D., Cornell University Medicine College, New York, N. Y. Advisor: Ira B. Black.
1982                 B.S., East China Normal Univ., Shanghai, P. R. China. Major: Biology.

[Selected Publications]

  • W. Guo, G. Nagappan and B. Lu*. (2018) Differential effects of transient and sustained activation of BDNF-TrkB signaling. Developmental Neurobiology. DOI 10.1002/dneu.22592.
  • K. Pang, H. You, Y. Chen, P. Chu, M. Hu5, J. -Y Shen, W. Guo, C. Xie, Bai Lu* (2017) MagR alone is insufficient to confer cellular calcium responses to magnetic stimulation. Frontiers Neural Circuits. 11:11.doi: 10.3389/fncir.2017.00011.
  • J. Guo, Y. Ji, Y. Ding, W. Jiang, Y. Sun, B. Lu*, G. Nagappan (2016) BDNF-pro peptide regulates dendritic spines via caspase-3. Cell Death & Differentiation. 7(6):e2264. doi: 10.1038/cddis.2016.166.
  • P. T. Pang, G. Nagappan, W. Guo, and B. Lu*(2016) Extracellular and intracellular cleavages of proBDNF required at two distinct stages of late phase LTP (L-LTP). Science of Learning. Published online 5,2016. doi:10.1038/npjscilearn.2016.3.
  • W. Guo, Y. Ji, S. Wang, Y. Sun, B. Lu* (2014) Neuronal activity alters BDNF- TrkB signaling kinetics and downstream functions. J. Cell Sci. 127, 2249-2260.
  • B. Lu* and G. Nagappan (2014) BDNF and synaptic plasticity. Handbook of Experimental Pharmacology. Springer-Verlag. Berlin. 233-250.
  • B. Lu*, P. J Nathan, Olivier Blin, G. Nagappan (2013) Synaptic function as a preclinical and experimental medicine readout for disease-modifying therapy in Alzheimer’s Disease. Drug Discovery Today: Therapeutic Strategies. 10, e99-104.
  • B. Lu*, G. Nagappan, X. Guan, P. J. Nathan and P. Wren (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nature Review Neuroscience. 14(6):401-16.
  • K. Sakata, K. Martinowich(co-first author), N. H. Woo, R. Schlosser, L. Shen, B. Lu* (2013) Activity-dependentBDNF transcription regulates hippocampal late-phase LTP and behavioral perseverance. Proc. Natl. Acad. Sci. USA. 10(37):15103-8.
  • H. –S. Je, F. Yang, Y. Ji, G. Nagappan, B. Hempstead, and B. Lu* (2012).Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.Proc. Natl. Acad. Sci. USA.109, 15924-15929.
  • K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. Hkfelt, A. Fisahn, B. Xu, and B. Lu* (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206.
  • Y. Jiao, Z. Zhang, C. Zhang, X. Wang, K. Sakata, B. Lu*, and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136.
  • Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu* (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309.
  • B. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu* (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204.
  • T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche, and B. Lu* (2009) Dysbindinregulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400.
  • Y. Ji, F. Yang, F. Papaleo, H. Wang, W. Gao, D. R. Weinberger, and B. Lu* (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98.
  • K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu* (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947.
  • G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu* (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272.
  • X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu*, and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158.
  • N. H. Woo, H.K. Teng, C.J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu* (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077.
  • Y. Ji, P. T. Pang, L. Feng, and B. Lu* (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172.
  • P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu* (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491.
  • M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, A. Bertolino, E. Zaistev, B. Gold, D. Goldman, M. Dean, B. Lu*,and D. R. Weinberger (2003)The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell112, 257-269.
  • C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu* (2001) Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release. Neuron 32, 99-112.
  • F. Yang, L. Feng, Z. Fang, S. W. Johnson, J. Du, L. Shen, C. -P. Wu, and B. Lu* (2001) GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons. Nature Neurosci. 4, 1071-1078.
  • F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong, and B. Lu* (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Nature Neurosci. 4, 19-28.
  • A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu* (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381, 706-709.            
  • P. Olafsson, T. Wang, and B. Lu* (1995) Molecular cloning and functional characterization of Xenopus Ca2+- binding protein frequenin. Proc. Natl. Acad. Sci. USA   92, 8001-8005.
  • T. Wang, Z. Xie, and B. Lu* (1995) Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses. Nature 374, 262-266.    
  • B. Lu*, W. -m. Fu, P. Greengard and M. -m. Poo (1993) Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction. Nature 363, 76-79.
  • B. Lu*, P. Greengard and M. -m. Poo (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron 8, 521-529.            
  • B. Lu*, M. Yokoyama, C. F. Dreyfus and I. B. Black (1991) Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 88, 6289-6292.