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Welcome to the online lecture, Tencent Conference ID: 308 178 161
Time: 14:00-15:30 on Tue., Dec. 15, 2020
Venue: E109, Biomedicine Hall
Host: Dr. Lingjie Kong
Learning can change neuronal activities in neocortex. However, the logic of how activities of individual neurons are transformed by learning and their roles in cortical processing of the learned stimuli remain unclear. By combining two-photon population Ca2+ imaging and single-cell loose-patch recordings in behaving mice, we found that learning transformed the sound-evoked response from a singlet firing mode to a high-rate bursting mode in a very sparse set of layer 2/3 neurons in primary auditory cortex. In mice trained with complex chords, we discovered cells with a ‘holistic bursting’ (HB) mode, exhibiting bursting responses specifically to a chord but not to any constituent tone. Strikingly, the inclusion of sparse HB cells, but not large numbers of nonbursting cells, was required by a neuronal population to achieve 100% accuracy in single-trial complex sound discrimination. Together, we find learning-transformed HB cells and their pivotal role in performing a cognitively meaningful information processing logic.