Lineage-dependent assembly of the functional neocortex.



Time: 15:00-16:30 , Nov. 19, 2015
Venue: .323,Medical Sciences Building
Speaker: Dr. Songhai Shi

Host: Dr. Yi Zhong
 The ability of the neocortex to command all higher-order brain functions depends on the intricate circuitry comprised of a vast number of diverse neurons. Despite advances in the understanding of the initial specification and the general histology and information flow of the neocortex, the principles and mechanisms that organize the assembly and operation of neocortical circuits remain elusive. Our work has focused on searching for the common commodities of neocortical circuits at both the structural and functional levels and linking them with animal behaviors. We have analyzed the mechanisms that control the production and positioning of neocortical neurons, with the premise that origin and lineage relationship guide the formation of reiterating neuronal ensembles/substrates for functional circuit assembly. I will discuss our previous and ongoing efforts.



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