Transcribing Memories

Time: 14:30-16:00, May 31, 2016
Venue: 143, Life Sciences Building, Tsinghua University
Speaker: Dr. Yingxi Lin

Host: Dr. Jisong Guan
How are transient experiences captured and stored in the brain? The main focus of my lab is to explore the cellular and molecular mechanisms by which experience is coupled to modifications of neural circuits that lead to long term behavioral changes. We study neuronal activity-regulated genetic programs triggered by experience, as they provide means to understanding not only how, but also where, specific experiences are captured in the brain. Our studies have recently revealed a critical, yet under-appreciated, role for activity-dependent transcription in maintaining the balance of neural circuits, which set the permissive stage for the formation of long term memory. I will also share with you the genetic tools that my lab has been developing that allow us to identify and manipulate neuronal ensembles activated by sensory and behavioral experiences. With these tools, we hope to uncover the underlying molecular and cellular mechanisms within the ensembles responsible for converting experience into long term memory.

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