Neuroscience CommunityBACK

Yao, Jun
Principal Investigator, McGovern Institute for Brain Research
Principal Investigator, School of Life Sciences
Principal Investigator, Tsinghua—Peking Joint Center for Life Sciences
Principal Investigator, State Key Laboratory of Biomembrane and Membrane Biotechnology
Lab homepage:
Lab Address: Medical Sciences Building D208
Lab Phone: 62797278
Email: jyao@mail.tsinghua.edu.cn, yaojun_ca@hotmail.com
LinkedIn:
[Research Focus] 1. Investigate the pathogenesis of neurological disorders using induced pluripotent stem cell technology;
2. Study the mechanisms underlying neurotransmitter release and synaptic vesicle cycling in the presynaptic nerve terminal using patch clamp recording and fluorescence imaging techniques.
3. Investigate synaptic plasticity in neurological disorders and neural network formation.
[Me & Science] In the central nervous system, synapse is the bridge for neurons to pass signals to each other. Synaptic dysfunction is involved in most types of neurological disorders including schizophrenia (SCZD) and Bipolar Disorder (BD), which are two typical complex neuropsychiatric diseases. On one hand, we are interested in studying the molecular mechanisms underlying synaptic vesicle cycling, by which neurotransmitters are efficiently released from the presynaptic nerve terminals to affect the downstream cells. On the other hand, we use human induced pluripotent stem cell disease model as a tool to investigate the synaptic relevant pathological mechanism of SCZD and BD neurons.
[Education & Experience] 2013- Principal Investigator, School of Life Sciences, Tsinghua University, China
2011-2013 Research Associate, Laboratory of Genetics, The Salk Institute for Biological Studies, USA
2007-2011 Postdoctoral Research Associate, Howard Hughes Medical Institute, University of Wisconsin, USA
2002-2007 Ph.D., The Pennsylvania State University, USA
1999-2001 M.S., Nanjing University, China
1995-1999 B. S., Nanjing University, China
[Selected Publications]

1.Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein Cell. 3(4):251-61. (Review)

2.Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER (2012). Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15(2): 243-249.

3.Yao J, Gaffaney JD, Kwon SE, Chapman ER (2011). Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147(3):666-77.

4.Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein & Cell. 3(4): 251-261. (Review)

5.Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER (2012). All three components of the neuronal SNARE complex contribute to secretory vesicle docking in PC12 cells. Journal of Cell Biology. 198(3):323-30.

6.Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER (2010). SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathogens. 6(11): e1001207.

7.Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B (2008). Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neuroscience. 38(2):277-289.

8.Deng, L.*, Yao, J.*, Fang, C., Dong, N., Luscher, B., Chen G (2007). Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience. 27(40):10860-9. (*Equal contribution)

9.Yao, J., Qi, J. S., and Chen, G (2006). Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience. 26(31):8137-47.

10.Qi, J., Yao, J., Fang, C., Luscher, B., and Chen G (2006). Downregulation of Tonic GABA Currents Following Epileptogenic Stimulation of Rat Hippocampal Cultures. Journal of Physiology. 577(2): 579-590.

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