Neuroscience CommunityBACK

Lu, Bai
Professor and Executive Vice Dean, School of Medicine, Tsinghua University
Office: Medical Sciences Building A311
Office Phone: 86-10-6278 5101
[Research Focus] Neuroscience, translational research, drug discovery
[Me & Science] Science to me is not just a profession, but a way of life – to help addressing societal needs, and to satisfy my intellectual curiosity. Students in my lab will learn how to think critically, and how to solve problems creatively.
[Education & Experience] 2013-Present Professor and Executive Vice Dean, School of Medicine, Tsinghua Univ., Beijing, China
2009-2013 Vice President, Biology, GlaxoSmithKline, R&D China, Shanghai, China
2008-2013 Adjunct Professor, School of Medicine, Tsnghua Univ., Beijing, China.
2004-2009 Associate Director of Molecular Neurobiology, Program in Gene, Cognition and Psychosis (GCAP), NIMH, NIH, Bethesda, M. D.
2002-2009 Chief, Section on Neural Development and Plasticity, NICHD, NIH, Bethesda, M. D.
1996-2002 Chief, Unit on Synapse Development and Plasticity, NICHD, NIH, Bethesda, M. D.
1993-1995 Assistant Prof., Roche Institute of Molecular Biology, Nutley, N. J.
1990-1993 Postdoctoral Fellow, with Paul Greengard, Rockefeller Univ. and Mu-ming Poo, Columbia Univ., New York, N. Y.
1990 Ph.D., Cornell University Medicine College, New York, N. Y. Advisor: Ira B. Black.
1982 B.S., East China Normal Univ., Shanghai, P. R. China. Major: Biology.
[Selected Publications]

1.K. Sakata, K. Martinowich(co-first author), N. H. Woo, R. Schlosser, L. Shen, B. Lu (2013) Activity-dependentBDNF transcription regulates hippocampal late-phase LTP and behavioral perseverance. Proc. Natl. Acad. Sci. USA.  110(37):15103-8.

2.H. –S. Je, F. Yang, Y. Ji, G. Nagappan, B. Hempstead, and B. Lu (2012).Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.Proc. Natl. Acad. Sci. USA.109, 15924-15929.

3.J. Y. Kim, C. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. S. Clair, K. Christian, J. H. Callicott, D. R. Weinberger, H. Song and G. -l. Ming (2012) Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia. Cell. 5, 1051-1064.

4.K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. Hökfelt, A. Fisahn, B. Xu, and B. Lu (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206.

5.Y. Jiao, Z. Zhang, C. Zhang, X. Wang,  K. Sakata, B. Lu, (co-corresponding author), and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136.

6.Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309.

7.B. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204.

8.T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche (co-corresponding author), and B. Lu (2009) Dysbindinregulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400.

9.Y. Ji, F. Yang, F. Papaleo (co-first author), H. Wang, W. Gao, D. R. Weinberger, and B. Lu (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98.

10.S. J, Huffaker, J. Chen, K. Nicodemus, F Sambataro, F. Yang, V. Mattay, B. Lipska, T. M. Hyde, J. Song, D. Rujescu, I. Giegling, K. Mayilyan, M. J. Proust, A. Soghoyan, G. Caforio, J. H. Callicott, A. Bertolino, A. Meyer-Lindenberg, J. Chang, Y. Ji, M. Egan, T. Goldberg, K. E. Kleinman, B. Lu, D. R. Weinberger (2009) A novel, primate-specific brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Medicine 5, 509-518. Commented in the same issue by Horvath and Mirnics, 488-590.

11.K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947.

12.G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272. Highlights by Katherine Whalley, Nature Rev. Neuroscie. 10, 168-169.  Commented in Alzheimer Research Forum by Lucia Tapia-Arancibia as well as Margaret Fahnestock.

13.J. J. An, K. Gharami, G. –Y. Liao, N. H. Woo, A. G. Lau, F. Vanevski, E. R. Torre, K. R. Jones, Y. Feng, B. Lu, B. Xu (2008) Distinct role of long 3’UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 134, 175-187.

14.X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu(co-corresponding author), and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158.

15.N. H. Woo, H.K. Teng, C. –J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077.Highlights by Morgan Sheng, Nature.442, 4.

16.Y. Ji, P. T. Pang, L. Feng, and B. Lu (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172. Feature article in AfCS Nature the signaling gateway, Feb, 2005, commented by MyrtoRaftopoulous.

17.P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491. Highlights by Rachel Jones, Nature Rev. Neuroscie.5, 898.Commented in Sci STKE, 255 tw378.Worldwide news coverage.

18.M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, A. Bertolino, E. Zaistev, B. Gold, D. Goldman, M. Dean, B. Lu, (co-corresponding author) and D. R. Weinberger (2003)The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function.Cell112, 257-269. With Preview by John Garbriele and Alison Preston, Cell 112, 144-145; News article by Jean Marx, Science, 299, 639-640. and Highlights by Magdalena Skipper, Nature Rev. Genetics. 4, 163.Worldwide news coverage.

19.C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu (2001) Ca2+-binding protein frequenin mediates GDNF-induced potentiation of Ca2+ channels and transmitter release. Neuron  32, 99-112.

20.F. Yang, L. Feng, Z. Fang, S. W. Johnson, J. Du, L. Shen, C. -P. Wu, and B. Lu (2001) GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons.  Nature Neurosci. 4, 1071-1078.

21.F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong, and B. Lu (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation.  Nature Neurosci.  4, 19-28. With News and Views comments by David Kaplan and Ellis Copper, 4, 5-7.

22.A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus.  Nature  381, 706-709.              

23.P. Olafsson, T. Wang, and B. Lu (1995)  Molecular cloning and functional characterization of Xenopus Ca2+- binding protein frequenin.  Proc. Natl. Acad. Sci. USA   92, 8001-8005.

24.T. Wang, Z. Xie, and B. Lu (1995) Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses.  Nature  374, 262-266.         Y.g-aminobutyratergic synaptic transmission in cortical neurons.    91, 12341-12345.  

25.B. Lu, W. -m. Fu, P. Greengard and M. -m. Poo (1993) Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction.  Nature  363, 76-79.

26.J. Alder, .B. Lu, F. Valtorta, P. Greengard and M. -m. Poo (1992) Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: Requirement for synaptophysin. Science257, 657-661.B. Lu, P. Greengard and M. -m. Poo (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron  8, 521-529.              

27.B. Lu, M. Yokoyama, C. F. Dreyfus and I. B. Black (1991) Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 88, 6289-6292.          

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