Neuroscience CommunityBACK

Shen, Qin
Associate Professor, School of Medicine

Office: D106, Medical Sciences Building 
Phone: +86 10 6279 8087

[Research Focus]

1. Molecular mechanism regulating neural stem cell self-renewal and fate choices
2. Interaction between neural stem cells and microenvironment (stem cell niche) which is critical for stem cell therapy
3. Stem cell function in neurological diseases
4. Human ES and iPS-derived neural stem cells for modeling developmental brain disorders

[Me & Science] The brain’s enormous cellular complexity and intricate structure attract active exploration of molecular mechanisms governing its development. The developing process unfolds with precise timing, ensuring that the nervous system is built region aside region, layer upon layer, networks arising and connecting, and choreographed with gliogenesis, ingrowth of other systems such as blood vessel formation and all within the wider context of embryogenesis. I have been always fascinated to think about how the brain is built to make who we are. The process is full of miracles and also full of mystery. The nervous system still remains the most difficult system to repair. The great cellular, molecular, structural and functional diversity presents significant hurdles for cell replacement strategies. Nevertheless, the devastating effects of neurodegenerative diseases, neurodevelopmental disorders and trauma provide strong impetus to understand the biology and disease etiology in the CNS, and to progress towards CNS therapeutic repair.
Our lab is interested in the development and maintenance of neural stem cells in the mammalian brain. Using a variety of approaches, we aim to probe how stem cells function in the developing brain, particularly the mechanisms of generating cellular diversity in the forebrain, and how the niche microenvironment affects self-renewal and fate choices of neural stem cells. We are also interested in using human pluripotent stem cells and neural stem cells as models to study the molecular mechanisms of human neural development and develop effective strategies for neural repair.
[Education & Experience]

2010-Present  Associate Professor, Tsinghua University
2007-2010  Assistant Professor, New York Neural Stem Cell Institute, New York, USA
2006-2010  Assistant Professor, Albany Medical Center, Center for Neuropharmacology and Neuroscience, New York, USA
2001-2006  Postdoc Fellow, Albany Medical College, Center for Neuropharmacology and Neuroscience
1996-2001  Ph.D., Albany Medical College, Center for Neuropharmacology and Neuroscience
1991-1996  Research and Teaching Assistant, Department of Neurobiology, State Key Laboratory of Medical Neurobiology, Shanghai Medical University (now Fudan University Shanghai Medical College)
1986-1991  B.S., Shanghai Medical University, School of Pharmacy, Pharmacology

[Selected Publications]

1. Kokovay E, Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q*, Temple S*.(2012)VCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression.Cell Stem Cell. 11(2):220-30. *co-corresponding authors
2. Chuang, S.M., Wang, Y., Wang, Q., Liu, K.M., Shen Q*.(2011) Ebf2 Marks Early Cortical Neurogenesis and Regulates the Generation of Cajal-Retzius Neurons in the Developing Cerebral Cortex. Dev Neurosci. 33(6):479-93. *corresponding author
3. Erzsebet, K., Goderie, S., Wang, Y., Lin, G., Roysam, B., Shen, Q., Temple, S. (2010) Adult SVZ lineage cells home to and leave the niche via differential responses to SDF1/CXCR4 signaling. Cell Stem Cell 7(2):163-173
4. Shen, Q.* and Temple, S. (2009) Fine control: microRNA regulates adult neurogenesis. Nature Neurosci.12 (4): 369-370
5. Kokovay, E., Shen, Q., Temple, S. (2008) The incredible elastic brain: how neural stem cells expand our minds. Neuron 60(3):420-9.
6. Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.M., Goderie, S.K., Roysam, B., Temple, S. (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3(3):289-300.
7. Shen, Q.*, Wang, Y., Dimos, J.T., Fasano, C.A., Phoenix, T.N., Lemischka, I.R., Ivanova, N.B., Stifani, S., Morrisey, E.E., Temple, S. (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nature Neurosci. 9(6):743-51
8. Shen, Q., Goderie, S., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., Temple, S. (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340
9. Li, H.S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., Jan, Y.N. (2003) Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40(6):1105-18.
10. Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002) Asymmetric m-Numb distribution is critical for asymmetric cell division of mouse cerebral cortical progenitor cells. Development 129:4843-4853.
11. Qian, X., Shen, Q.,Goderie, S., He, W., Capela, A.M., and Temple, S. (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical cells. Neuron 28:69-80. co-first author
12. Qian, X., Goderie, S., Shen, Q., Stern, J. H. and Temple, S. (1998)Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells. Development 125:3143-3152

For the full list of publication, please click HERE:

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