Neuroscience CommunityBACK

Guan, Jisong
Professor, School of Life Sciences, Tsinghua University
Office: D206, Medical Sciences Building
Office Phone: 86-10-62785905
Lab Phone: 86-10-62781383
[Research Focus] Neurological defects in memory lead to the loss of selfness, the loss of one’s life history, and the loss of enduring interactions with others, which can be seen in various diseases, such as Alzheimers's disease, Schizophrenia and Mental Retardation. The current research interest of our lab is to explore the activity dynamics at molecular, cellular and circuitry level within cortical circuits that underlies the encoding, storage and recall of specific information in mammalian brain.
1. Epigenetic mechanisms underlying cellular memory: a) Activation induced epigenetic regulation on neuronal excitability and plasticity. b) Epigenetic mechanisms on the maintenance of cellular memory. c) Epigenetic abnormalities in Alzheimers's disease, Schizophrenia and Mental Retardation.
2. Circuit mechanism for memory coding: a) To develop new molecular probes and software analysis tools to monitor neuronal activity dynamics in free-moving mice during learning. b) Cortical representation and storage of the integrated multi-sensory information. c) Biological coding based Brain-Machine Interface. To establish the information transition between the brain-network and the machine, using the brain orientated decoding and encoding mechanisms via optogenetic approaches and optical imaging approaches.
[Education & Experience]

2011-present     Professor, School of Life Sciences, Tsinghua University

                        Principle Investigator, Center for life sciences
2007- 2010       Postdoctoral research fellow, Stanley Center for Psychiatric Research, Broad Institute, Cambridge, Massachusetts, USA
2006-2010       Postdoctoral research fellow, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
2001-2006       Ph.D. in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai, P.R. China
1997-2001       B.S. in Biochemistry, Department of Biochemistry, Nanjing University, Nanjing, P.R.China

[Selected Publications]

1.Hong Xie, Yu Liu, Youzhi Zhu, Xinlu Ding, Yuhao Yang, Ji-Song Guan#.. In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2788-93.

2.Seo, J., Giusti-Rodriguez, P., Zhou, Y., Rudenko, A., Cho, S., Ota, K.T., Park, C., Patzke, H., Madabhushi, R., Pan, L. Mungenast AE, Guan JS, Delalle I, Tsai LH. Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Abeta-Induced Cognitive Impairment. Cell. 2014 Apr 10;157(2):486-98.  

3.Hong Xie, JiSong Guan, Laura A. Borrelli, Jing Xu, Alberto Serrano-Pozo, and Brian J. Bacskai, Mitochondrial Alterations near Amyloid Plaques in an Alzheimer's Disease Mouse Model. J. Neuroscience, 2013, 33(43):17042-17051

4.Zhang J, Cao Q, Li S, Lu X, Zhao Y, Guan JS, Chen JC, Wu Q, Chen GQ.3-hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism. Biomaterials. 2013 Oct;34(30):7552-62.

5.Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 2013 Jan;64:81-96.

6.Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature. 2012 Feb 29;483(7388):222-6.

7.Guan JS*, Su SC*, Gao J, Joseph N, Xie Z, Zhou Y, Durak O, Zhang L, Zhu JJ, Clauser KR, Carr SA, Tsai LH. Cdk5 Is Required for Memory Function and Hippocampal Plasticity via the cAMP Signaling Pathway. PLoS One. 2011; 6(9): e25735.  Epub 2011 Sep 30.

8.Shao-Qiu He*, Zhen-Ning Zhang*, Ji-Song Guan*, Hong-Rui Liu, Bo Zhao, Hai-Bo Wang, Qian Li, Hong Yang, Jie Luo, Zi-Yan Li, Lan Bao & Xu Zhang. Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Co-Degradation. Neuron, 2011

9.Jun Gao*, Wen-Yuan Wang*, Ying-Wei Mao, Johannes Gra¨ff, Ji-Song Guan, Ling Pan, Gloria Mak, Dohoon Kim, Susan C. Su & Li-Huei Tsai. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature, 466(7310):1105-9 2010

10.Ji-Song Guan*, Stephen J. Haggarty*, Emanuela Giacometti*, Jan-Hermen Dannenberg*, Nadine Joseph, Jun Gao, Thomas J.F. Nieland, Ying Zhou, Xinyu Wang, Ralph Mazitschek, James E. Bradner, Ronald A. DePinho, Rudolf Jaenisch, Li-Huei Tsai. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459(7243): 55-60; May 2009 (full research article)

11.Dohoon Kim, Christopher L. Frank, Matthew M. Dobbin, Rachel K. Tsunemoto, Weihong Tu, Peter L. Peng, Ji-Song Guan, Byung-Hoon Lee, Lily Y. Moy, Paola Giusti, Nisha Broodie, Ralph Mazitschek, Ivanna Delalle, Stephen J. Haggarty, Rachael L. Neve, YouMing Lu and Li-Huei Tsai. Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity. Neuron 60(5):803-17; Dec 2008

12.Hai-Bo Wang, Ji-Song Guan, Lan Bao and Xu Zhang. Distinct Subcellular Distribution of δ-Opioid Receptor Fused with Various Tags in PC12 Cells. Neurochemical Research, 33(10):2028-34 Oct 2008

13.Ji-Song Guan*, Zhen-Zhong Xu*, Hua Gao, Shao-Qiu He, Guo-Qiang Ma, Tao Sun, Li-Hua Wang, Zhen-Ning Zhang, Isabelle Lena, Ian Kitchen, Robert Elde, Andreas Zimmer, Cheng He, Gang Pei, Lan Bao and Xu Zhang. Interaction with Vesicle Luminal Protachykinin Regulates Surface Expression of δ-Opioid Receptors and Opioid Analgesia.  Cell 122: 619-631, 2005

15.Xu Zhang, Lan Bao, Ji-Song Guan. Role of delivery and trafficking of δ-opioid receptors in opioid analgesia and tolerance. Trends in pharmacological sciences , 27 (6): 324-329 JUN 2006 (Review)

14.Lan Bao*, Shan-Xue Jin*, Chen Zhang*, Li-Hua Wang, Zhen-Zhong Xu, Fang-Xiong Zhang, Lie-Chen Wang, Feng-Shou Ning, Hai-Jiang Cai, Ji-Song Guan, Hua-Sheng Xiao, Zhi-Qing D. Xu, Cheng He, Tomas Hökfelt, Zhuan Zhou, and Xu Zhang. Activation of Delta Opioid Receptors Induces Receptor Insertion and Neuropeptide Secretion. Neuron 37, 121-133,2003

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