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Ou,Guangshuo
Principal Investigator, McGovern Institute for Brain Research
Principle Investigator, School of Life Sciences
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Office Phone: +86-10-62794766
Email: guangshuo.ou@gmail.com
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[Research Focus] Our laboratory aims to understand how cytoskeleton and signaling-related biomacromolecules regulate neural progenitors to divide, migrate, differentiate and die using Caenorhabditis elegans as the model system. We developed fluorescence time-lapse imaging techniques to visualize neuroblast development in live animals, and we have also developed C. elegans conditional knockout methods to dissect the underlying molecular mechanisms.
[Education & Experience] 2013-present, Principal Investigator, School of Life Sciences, Tsinghua University
2011-2013 Professor, Institute of Biophysics, Chinese Academy of Sciences
2007-2011 Postdoctoral Research Fellow, University of California, San Francisco/HHMI
2001-2006 Ph.D. Cell & Developmental Biology, University of California, Davis
1994-2001 B.S. & M.S. China Agricultural University, College of Biological Sciences
[Selected Publications]

1.    Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *, and Ou G.* (2013)  Conditional targeted genome editing using somatically expressed TALENs in C. elegans. Nature Biotechnology. 2013 Aug 18.  

2.    Feng G, Yi P,  Yang Y, Chai Y, Tian D, Zhu Z, Liu J, Zhou F, Cheng Z, Wang X, Li W, and Ou G.* (2013) . Developmental Stage-Dependent Transcriptional Regulatory Pathways Control Neuroblast Lineage Progression. Development. 2013 Aug 14.  

3.    Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, Feng G, Li W, and Ou G.* (2013) Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11175-80.  

4.    Chai Y, Tian D, Feng G, Cheng Z, Yang Y, Li W and Ou, G.* (2012)  Apoptotic Regulators Promote Midbody Degradation in C. elegans. Journal of Cell Biology. 2012 Dec; 199(7):1047-55.  

5.    Chai Y, Li W, Feng G, Yang Y, Wang X and Ou, G.* (2012)  Live Imaging of Cellular Dynamics during C. elegans Postembryonic Development. Nature Protocols.  2012 Nov; 7(12):2090-102.  

6.    Li W, Zou W, Yang Y, Chai Y, Chen B, Cheng S, Tian D, Wang X*, Vale RD* and Ou, G.* (2012) Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell. Journal of Cell Biology. 197(1):27-35.  

7.    Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677  

8.    Ou, G. and R.D. Vale (2009) Molecular signatures of cell migration in C. elegans Q neuroblasts.  Journal of Cell Biology. 185: 77-85.

9.    Ou G, Koga M, Blacque OE, Murayama T, Ohshima Y, Schafer JC, Li C, Yoder BK, Leroux MR, Scholey JM. (2007) Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Molecular Biology of the Cell. 18(5):1554-69.

10.    Pan, X. †, Ou, G. †, Civelekoglu-Scholey, G., Blacque, O.E., Endres, N.F., Li, T., Mogilner, A., Leroux, M.R., Vale, R.D. and J.M. Scholey. (2006) Mechanism of transport of IFT-particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. Journal of Cell Biology. 174(7):1035-45.  

11.    Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature.  436(7050):583-7.  

12.    Ou, G.†, Qin, H.†, Rosenbaum, JL and JM Scholey (2005) The PKD protein qilin undergoes intraflagellar transport. Current Biology. 15(11):R410-1.

13.    Snow, J.†, Ou, G.†, Gunnarson, A, Walker, R, Zhou, HM, Brust-Mascher, I and Scholey JM (2004) Two Anterograde Intraflagellar Transport Motors Cooperate to Build Sensory Cilia on C. elegans Neurons. Nature Cell Biol. 6(11):1109-13.  

14.    Ou GS†, Chen ZL†, Yuan M. (2002) Jasplakinolide reversibly disrupts actin filaments in suspension-cultured tobacco BY-2 cells. Protoplasma. 219(3-4):168-75.

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