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Xiong, Wei
Principle Investigator, THU IDG/McGovern Institute
Assistant Professor, School of Life Sciences, Tsinghua University
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[Research Focus] 1. Molecular mechanisms of hair-cell mechanotransduction
2. Annotation of deafness genes
3. Neural circuits of auditory pathways
[Me & Science] Hearing impairment is a common sensory and communication disorder. Human patients with this disorder have difficulty in perceiving alerts, appreciating music and especially conversation. Auditory hair cells convert sound information into electrical signals that are then relayed to the brain, which make them as a major target in developing therapeutic approaches for preventing and treating hearing impairment. My research has been studying molecular and cellular mechanisms of hair-cell mechanotransduction that are critical for sound detection. In our lab, we are determining genes linked to hearing loss and elucidating the underlying mechanisms. Our long-term goal is to understand the molecular basis of the hair-cell physiology and auditory plasticity in developing and diseased brains.
[Education & Experience] 2014-present, Assistant Professor, School of Life Sciences, Tsinghua University 
2007-2014, Postdoctoral Research Associate, The Scripps Research Institute, La Jolla 
2006-2007, Assistant Investigator, Institute of Molecular Medicine, Peking University 
2000-2006, Ph.D., Neurobiology, Institute of Neuroscience, CAS 
1995-1999, B.S., Microbiology, Wuhan University
[Selected Publications]

Zheng, L., Wang, C., Shang, S., Zhang, X., Wang, Y., Wu, Q., Hu, M., Chai, Z., Wu, X., Zheng, H., Zhang, C., Wang, L., Xiong, W.#, and Zhou, Z.# “Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells,” Am J Physiol Cell Physiol 305, no. 7 (2013): p. 751-60.

Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F.J., Zhao, B., Johnson, K. R., Kazmierczak, P. and Müller, U., “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells,” Cell 151, no. 6 (2012): p. 1283-95.    

Xiong, W.*, Liu, T.*, Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C. X. and Zhou, Z., "An Inhibitory Effect of Extracellular Ca on Ca-Dependent Exocytosis," PLoS One 6, no. 10 (2011): e24573.

Grillet, N.*, Xiong, W.*, Reynolds, A.*, Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. and Müller, U., "Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells," Neuron 62, no. 3 (2009): 375-387.  

Wang, L. C.*, Xiong, W.*, Zheng, J., Zhou, Y., Zheng, H., Zhang, C., Zheng, L. H., Zhu, X. L., Xiong, Z. Q., Wang, L. Y., Cheng, H. P. and Zhou, Z., "The Timing of Endocytosis after Activation of a G-Protein-Coupled Receptor in a Sensory Neuron," Biophys J 90, no. 10 (2006): 3590-3598.

Zhang, C.*, Xiong, W.*, Zheng, H., Wang, L., Lu, B. and Zhou, Z., "Calcium- and Dynamin-Independent Endocytosis in Dorsal Root Ganglion Neurons," Neuron 42, no. 2 (2004): 225-236.

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